AthenaDAO: Demystifying the ‘Biological Clock’ & Menopause with IP-NFTs

As the world changes, many people are choosing to have children later in life. While the term ‘biological clock’ gets thrown around loosely, the reality is that very few people are educated about or prepared for the fertility issues that can ensue.  

Ovarian aging is a multi-step process, culminating in menopause, and a complete inability to bear children. The trait is governed by several factors including age, genetics, lifestyle, health conditions, medical treatments, and weight - simply put, there is no ‘one-size-fits-all’ model. Countless women are sent home from fertility doctors with deep emotional, physical and financial wounds, but no answers as to why they are struggling to fall pregnant. AthenaDAO exists to advocate for all those impacted by reproductive decline (among other things) and is vivaciously pursuing solutions.

Estimates suggest that one in six people experience fertility issues during their lifetime. Dr Mario Cordero and his wife formed part of this number; after suffering problems in conceiving due to ovarian aging the two had to turn to fertility treatments. Their story ended happily with a beautiful daughter named Martina, but the experience roused something in Mario, leading him to dedicate his life to the field of ovarian aging. Having been at the final stages of the fertility treatment pipeline, Mario understands that the work done in a laboratory needs to be able to be transported out of a petri dish and to patients, in order for it to make a recognisable impact in peoples’ lives. It is this sentiment that rang true to AthenaDAO, which primarily focuses on funding translational research to improve the female experience. AthenaDAO has dedicated $120 000 to Mario and his work with Pablo de Olavide University to combat ovarian aging. 

Dr Mario Cordero in his lab in Seville, Spain

The Role of Inflammation in Ovarian Aging

Chronic inflammation is hugely detrimental to our health. In fact, it is one of the infamous and well-recognized ‘Hallmarks of Aging’ which detail the primary risk factors that result in a bodily decline. Unsurprisingly, inflammation in the ovaries is dangerous yet frequently overlooked. It is a cause of a Diminished Ovarian Reserve (DOR), which renders women infertile. 

As a recognized expert in the field of inflammation in reproductive longevity, the funding from AthenaDAO will allow Mario to tackle the root of inflammation responsible for a diminishing ovarian reserve, via the inhibition of the cGAS-STING pathway. Using state-of-the-art animal models and having access to patient tissue samples, Mario's research group is exceptionally positioned to develop novel inhibitors as a tailor-made treatment opportunity for women in need. As , Core Lead of AthenaDAO says; “If you understand the pathways of ovarian aging, you have the potential to treat them.”