Prima Donna

Introducing Project Prima Donna: the first-ever treatment designed to regenerate lost enamel to keep you smiling for a lifetime. Enamel erosion is an irreversible, age-related condition that no one is immune from, leading to tooth sensitivity, cavities, and more severe health complications. Current solutions, such as fluoride rinses, crowns, or veneers, merely mask the problem without addressing the root cause.

Spearheaded by renowned stem cell researchers and dentists Dr. Hannele Ruohola-Baker, Dr. Julie Mathieu, and Dr. Jonathan An, this project utilizes breakthroughs in induced pluripotent stem cell (iPSC) technology to develop enamel-regenerating organoids. These organoids have shown promising results in the lab and are now ready for testing in a relevant animal model. This is an important step towards developing a drug that can move us beyond mere symptom management, to restore our natural ability to produce enamel.

The global economic burden of poor oral health was estimated to be $544 billion in 2015, and oral health is the most prevalent non-transmissible disease worldwide. If successful, this treatment stands to significantly reduce the global burden of dental diseases and healthcare costs. Join us on our journey to revolutionize oral health and to create a future where aging never dims your brilliant smile.