# Research plan: Evidence mapped fracture recovery The Reknit Lab is launching a computational and agent supported programme to map the state of the art in fracture healing and functional recovery, beginning with radial head fractures as the initial model. ## Research questions Across orthopaedics, mechanobiology, pharmacology, rehabilitation science, nutrition, local therapies and medical devices, the Lab will assess which interventions may: shorten time to bone union; improve the quality and strength of healed bone; and restore full range of motion, especially extension and forearm rotation, where stiffness is a common long term deficit. ## Evidence framework Human clinical evidence will be evaluated separately from animal and preclinical findings. Rehabilitation protocols, drugs and nutritional agents, topical or local therapies, and devices such as pulsed electromagnetic field therapy and low intensity pulsed ultrasound will be graded by: evidence level; effect size; safety; and actionability: **actionable now**, **promising** or **unsupported**. ## Planned outputs A living state of the art review A confidence graded interventions matrix An evidence based rehabilitation timeline with decision points A prioritised list of research gaps The Lab will also identify open questions and testable combinations where outcomes might exceed pre injury baseline, including optimally timed mechanical loading, targeted nutrition and structured progressive strengthening after union. ## Clinical use boundary These findings are intended as decision support for clinicians and patients, not as medical advice. Any pharmacological or device based option must be reviewed by an appropriately qualified clinician before use. - Reknit

# Research plan: Evidence mapped fracture recovery The Reknit Lab is launching a computational and agent supported programme to map the state of the art in fracture healing and functional recovery, beginning with radial head fractures as the initial model. ## Research questions Across orthopaedics, mechanobiology, pharmacology, rehabilitation science, nutrition, local therapies and medical devices, the Lab will assess which interventions may: shorten time to bone union; improve the quality and strength of healed bone; and restore full range of motion, especially extension and forearm rotation, where stiffness is a common long term deficit. ## Evidence framework Human clinical evidence will be evaluated separately from animal and preclinical findings. Rehabilitation protocols, drugs and nutritional agents, topical or local therapies, and devices such as pulsed electromagnetic field therapy and low intensity pulsed ultrasound will be graded by: evidence level; effect size; safety; and actionability: **actionable now**, **promising** or **unsupported**. ## Planned outputs A living state of the art review A confidence graded interventions matrix An evidence based rehabilitation timeline with decision points A prioritised list of research gaps The Lab will also identify open questions and testable combinations where outcomes might exceed pre injury baseline, including optimally timed mechanical loading, targeted nutrition and structured progressive strengthening after union. ## Clinical use boundary These findings are intended as decision support for clinicians and patients, not as medical advice. Any pharmacological or device based option must be reviewed by an appropriately qualified clinician before use. - Reknit | Molecule