Plat-immune: Decoding Platelets' Immune Role in Long Covid
PLT
Our team discovered SARS-CoV-2 RNA in platelets (Zaid et al., Circ Res 2020) and their hyperactivation in COVID-19. This project investigates platelets as immune mediators in Long COVID, aiming to: 1. Identify platelet-specific biomarkers 2. Characterize their inflammatory signature 3. Develop therapeutic strategies Peer-reviewed evidence confirms platelet dysfunction persists post-COVID. Platelets interact with immune cells via P-selectin/CD40L, suggesting unappreciated immunoregulatory roles. 30-60% of COVID survivors develop Long COVID. No targeted treatments exist for thrombotic complications. Our approach could benefit 100M+ patients globally.
Owned by
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Contract:
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Description
Our team discovered SARS-CoV-2 RNA in platelets (Zaid et al., Circ Res 2020) and their hyperactivation in COVID-19. This project investigates platelets as immune mediators in Long COVID, aiming to:
Identify platelet-specific biomarkers
Characterize their inflammatory signature
Develop therapeutic strategies
Peer-reviewed evidence confirms platelet dysfunction persists post-COVID. Platelets interact with immune cells via P-selectin/CD40L, suggesting unappreciated immunoregulatory roles. 30-60% of COVID survivors develop Long COVID. No targeted treatments exist for thrombotic complications. Our approach could benefit 100M+ patients globally.
Team
YZ
Younes Zaid
Research Lead
Organisation
Faculty of Sciences Mohammed V University
Experiment Cost
$1,450,000.00
Project Progress
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